Josh Allen’s 26-yard touchdown run on fourth-and-2 with just over two minutes left sealed the Bills’ 30-21 win in Orchard Park, N.Y., on Sunday as Buffalo dealt the Kansas City Chiefs their first loss of the season.

Facing the choice of attempting a short field goal or handing the two-time defending Super Bowl champions and quarterback Patrick Mahomes the ball with time to drive downfield for a win, Bills coach Sean McDermott turned the game over to Allen, who first looked to pass, then diced through a Chiefs defense that is among the league’s best against the run.

Allen completed 27 of 40 passes for 262 yards and led the Bills (9-2) with 55 rushing yards.

With Buffalo’s defense containing Mahomes, Allen bloomed in the fourth quarter. His 12-yard scoring pass to Curtis Samuel with 12:51 left punctuated a 10-play, 83-yard drive that took just over six minutes off the clock and gave the Bills a 23-14 lead.

But Mahomes led the Chiefs 70 yards in 4:58 to trim Buffalo’s lead to 23-21 on his second touchdown pass of the day — a 1-yarder — to tight end Noah Gray. Mahomes finished with 196 yards, three TDs and two interceptions on 23-of-33 passing for Kansas City (9-1).

Steelers 18, Ravens 16

Chris Boswell kicked six field goals in a game for the third time in his career and Pittsburgh remained in first place in the AFC North with a victory over visiting Baltimore.

Russell Wilson completed 23 of 36 passes for 205 yards and one interception for the Steelers (8-2), who won their fifth straight game. Payton Wilson made a key interception as Pittsburgh increased its division lead to 1 1/2 games over the Ravens (7-4).

Baltimore’s Lamar Jackson was just 16-of-33 passing for 207 yards, one touchdown and an interception while dropping to 1-4 all-time as a starter against the Steelers. Derrick Henry rushed for 65 yards and a score on 13 carries and Odafe Oweh had 2 1/2 sacks for the Ravens, who committed three turnovers and lost for just the second time in their past nine games.

Packers 20, Bears 19

Quarterback Jordan Love passed and ran for a touchdown, Karl Brooks blocked a field goal as time expired and visiting Green Bay edged skidding Chicago.

Love scored the go-ahead TD on a 1-yard run with 2:59 to go. Rookie counterpart Caleb Williams drove the Bears downfield on the next possession, positioning them for a would-be game-winning 46-yard field goal. But Brooks blocked Cairo Santos’ kick to help Green Bay (7-3) preserve the victory.

Love went 13-for-17 passing for 261 yards with a touchdown and an interception. Josh Jacobs had 134 yards of total offense and a rushing touchdown, and Christian Watson had a career-high 150 yards on four catches. Williams was 23-for-31 passing for 231 yards and added 70 yards on nine carries as Chicago (4-6) lost its 11th straight game in the all-time series with the Packers.

Lions 52, Jaguars 6

Jared Goff passed for a season-high 412 yards and four touchdowns as host Detroit stretched its winning streak to eight games — its longest in the Super Bowl era — by pounding Jacksonville.

Detroit’s Amon-Ra St. Brown caught 11 passes for 161 yards and scored two touchdowns, while David Montgomery rushed for 75 yards and two scores. Goff bounced back from a five-interception outing against the Houston Texans as the Lions (9-1) scored touchdowns on their first seven possessions en route to their most lopsided win in franchise history.

Mac Jones passed for 138 yards and was intercepted once as the Jaguars (2-9) lost their fourth straight game. Jones got the start again after No. 1 quarterback Trevor Lawrence missed his second straight game with a shoulder injury.

Dolphins 34, Raiders 19

Jonnu Smith caught six passes for a career-high 101 yards and two touchdowns and Tua Tagovailoa threw three touchdown passes to lead Miami over Las Vegas in Miami Gardens, Fla.

Tagovailoa completed 28 of 36 passes for 288 yards and no interceptions for the Dolphins (4-6). He tossed a 57-yard touchdown to a wide-open Smith over the middle with 3:19 remaining in the fourth quarter to make it 31-19, and Jalen Ramsey sealed the outcome by intercepting Gardner Minshew on the first play of the Raiders’ ensuing series.

Minshew completed 30 of 43 passes for 282 yards and two touchdowns as the Raiders (2-8) dropped their sixth game in a row. His favorite target was rookie tight end Brock Bowers, who gave Miami’s defense fits by catching 13 passes for 126 yards and a touchdown.

Rams 28, Patriots 22

Matthew Stafford threw for 295 yards and four touchdowns as Los Angeles held off New England in Foxborough, Mass.

Puka Nacua hauled in seven catches for 123 yards and a score for the Rams (5-5), while Cooper Kupp finished with six catches for 106 yards and two TDs. Drake Maye finished with 282 yards, two TDs and a pick on 30-of-40 passing for the Patriots (3-8).

Los Angeles carried a 28-13 lead into the fourth quarter, but the Patriots began to rally with Maye’s 4-yard touchdown pass to left tackle Vederian Lowe and Joey Slye’s 42-yard field goal. Slye had his extra point blocked following Lowe’s catch in the end zone. New England ended up getting the ball back with 2:14 left in the game, but Maye was picked off by Kamren Kinchens with 1:55 remaining to kill the comeback bid.

Saints 35, Browns 14

Taysom Hill rushed for 138 yards and three touchdowns, Derek Carr threw two touchdown passes and host New Orleans defeated Cleveland.

Carr passed for 248 yards and Hill added a career-high eight receptions for 50 yards as the Saints (4-7) improved to 2-0 under interim coach Darren Rizzi.

For the Browns (2-8), former Saints quarterback Jameis Winston passed for 395 yards and two touchdowns, one of which went to Jerry Jeudy, who finished with 142 yards on six catches.

Colts 28, Jets 27

Anthony Richardson threw for 272 yards and accounted for three touchdowns, including a game-winning 4-yard scoring run with 46 seconds left, as Indianapolis rallied to beat New York in East Rutherford, N.J.

Richardson completed 20 of 30 passes in his return to the starting lineup after being benched for two weeks in favor of Joe Flacco. The Colts (5-6) finished with 332 total yards of offense and controlled the ball for more than 34 minutes.

Aaron Rodgers hit 22 of 29 passes for 184 yards and two touchdowns for the Jets, finding Kenny Yeboah for an 11-yard scoring strike less than two minutes into the fourth quarter for a 24-16 advantage. But Rodgers couldn’t do anything on New York’s last drive, taking two sacks. The Jets fell to 3-8 with their seventh loss in eight games despite 121 total yards from scrimmage by Breece Hall, who scored two touchdowns.

Vikings 23, Titans 13

Sam Darnold completed 20 of 32 passes for 246 yards and two touchdowns and rushed for another score as Minnesota posted a win over Tennessee in Nashville.

Jordan Addison and Cam Akers had one touchdown catch apiece for the Vikings (8-2), who won their third game in a row and remained one game behind Detroit in the NFC North.

Will Levis completed 17 of 31 passes for 295 yards, one touchdown and one interception for the Titans (2-8), who have lost five of their past six games. Nick Westbrook-Ikhine had a 98-yard touchdown catch.

Broncos 38, Falcons 6

Rookie quarterback Bo Nix completed 28 of 33 passes for career highs of 307 yards and four touchdowns as Denver dominated visiting Atlanta.

Javonte Williams ran for 59 yards and a score while Courtland Sutton caught seven passes for 78 yards for the Broncos (6-5), who snapped a two-game losing streak. Lil’Jordan Humphrey, Marvin Mims Jr., Troy Franklin and Nate Adkins each hauled in a touchdown pass.

The Falcons (6-5) were held without a touchdown for the first time this season and lost their second straight game. Kirk Cousins completed 18 of 27 passes for 173 yards and threw one interception. Drake London had three catches for 61 yards as Atlanta was outgained 400-226.

Seahawks 20, 49ers 17

Geno Smith scored on a 13-yard scramble with 12 seconds remaining as Seattle upended San Francisco in Santa Clara, Calif.

The Seahawks (5-5) snapped a two-game skid and won for just the second time in their past seven games. Smith was 25-of-32 passing for 221 yards and one interception. Jaxon Smith-Njigba made 10 catches for 110 yards.

Brock Purdy was 21-of-28 passing for 159 yards, throwing for one touchdown and rushing for another for the 49ers (5-5). Purdy was picked off once. Christian McCaffrey, playing in his second game of the season after recovering from Achilles tendinitis, finished with 106 total yards of offense (79 rushing, 27 receiving).